SCOP 1.75: Domain d2gfdb1: 2gfd B:74-337

Lineage for d2gfdb1 (2gfd B:74-337)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (4 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (1 protein)

6. Protein HSP90 [55876] (3 species)

7. Species Dog (Canis familiaris) [TaxId:9615] [103225] (20 PDB entries)
   Uniprot P41148 76-285; Endoplasmin, GRP94

8. Domain d2gfdb1: 2gfd B:74-337 [135095]
   automatically matched to d1u2oa_
   complexed with 1pe, pg4, rda; mutant

Details for d2gfdb1

PDB Entry: 2gfd, 2.3 Å

PDB Description: grp94 in complex with the novel hsp90 inhibitor radamide

PDB Compounds: (B:) Endoplasmin

SCOP Domain Sequences for d2gfdb1:

Sequence, based on SEQRES records:

>d2gfdb1 d.122.1.1 (B:74-337) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqstselig
qfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlke
easdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

Sequence, based on observed residues (ATOM records):

>d2gfdb1 d.122.1.1 (B:74-337) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiagtseflnkmteaqstseligqfgvgf
ysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdyl
eldtiknlvkkysqfinfpiyvwssktktvwdwelmn

Timeline for d2gfdb1:

• d2gfdb1 first appeared in SCOP 1.73
  
• d2gfdb1 is called d2gfdb_ in SCOPe 2.01
  
• d2gfdb1 appears in the current release, SCOPe 2.08, called d2gfdb_