SCOP 1.75: Domain d2gc8a1: 2gc8 A:1-562

Lineage for d2gc8a1 (2gc8 A:1-562)

1. Root: SCOP 1.75

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (2 proteins)

6. Protein Viral RNA polymerase [56695] (10 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (21 PDB entries)

8. Domain d2gc8a1: 2gc8 A:1-562 [134970]
   automatically matched to d1nhvb_
   complexed with 885

Details for d2gc8a1

PDB Entry: 2gc8, 2.2 Å

PDB Description: Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase

PDB Compounds: (A:) RNA-directed RNA polymerase

SCOP Domain Sequences for d2gc8a1:

Sequence, based on SEQRES records:

>d2gc8a1 e.8.1.4 (A:1-562) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d2gc8a1 e.8.1.4 (A:1-562) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
dlsgwfvagysggdiyh

Timeline for d2gc8a1:

• d2gc8a1 first appeared in SCOP 1.73
  
• d2gc8a1 is called d2gc8a_ in SCOPe 2.01
  
• d2gc8a1 appears in the current release, SCOPe 2.08, called d2gc8a_