SCOPe 2.07: Domain d2fzza_: 2fzz A:

Lineage for d2fzza_ (2fzz A:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein automated matches [190044] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187233] (166 PDB entries)

8. Domain d2fzza_: 2fzz A: [134486]
   Other proteins in same PDB: d2fzzl_
   automated match to d1c5md_
   complexed with 5qc

Details for d2fzza_

PDB Entry: 2fzz, 2.2 Å

PDB Description: Factor Xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one

PDB Compounds: (A:) coagulation factor x

SCOPe Domain Sequences for d2fzza_:

Sequence; same for both SEQRES and ATOM records:

>d2fzza_ b.47.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt

Timeline for d2fzza_:

• d2fzza_ first appeared in SCOP 1.73, called d2fzza1
  
• d2fzza_ appears in SCOPe 2.06
  
• d2fzza_ appears in the current release, SCOPe 2.08