Lineage for d2fzia_ (2fzi A:)

  1. Root: SCOPe 2.01
  2. 968085Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1004246Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 1004247Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 1004248Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 1004391Protein Dihydrofolate reductases, eukaryotic type [53605] (6 species)
  7. 1004404Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (19 PDB entries)
  8. 1004408Domain d2fzia_: 2fzi A: [134448]
    automated match to d1cd2a_
    complexed with dh3, nap

Details for d2fzia_

PDB Entry: 2fzi (more details), 1.6 Å

PDB Description: New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d2fzia_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2fzia_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Fungus (Pneumocystis carinii) [TaxId: 4754]}

SCOPe Domain Coordinates for d2fzia_:

Click to download the PDB-style file with coordinates for d2fzia_.
(The format of our PDB-style files is described here.)

Timeline for d2fzia_: