Lineage for d2fzha_ (2fzh A:)

  1. Root: SCOPe 2.02
  2. 1143363Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1180768Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 1180769Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 1180770Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 1180914Protein Dihydrofolate reductases, eukaryotic type [53605] (6 species)
  7. 1180927Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (23 PDB entries)
  8. 1180948Domain d2fzha_: 2fzh A: [134447]
    automated match to d1cd2a_
    complexed with dh1, nap

Details for d2fzha_

PDB Entry: 2fzh (more details), 2.1 Å

PDB Description: New Insights into Dihydrofolate Reductase Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d2fzha_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2fzha_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Fungus (Pneumocystis carinii) [TaxId: 4754]}

SCOPe Domain Coordinates for d2fzha_:

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Timeline for d2fzha_: