SCOPe 2.05: Domain d2fysa_: 2fys A:

Lineage for d2fysa_ (2fys A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase Erk2 [56134] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (27 PDB entries)

8. Domain d2fysa_: 2fys A: [134389]
   automated match to d1erk__

Details for d2fysa_

PDB Entry: 2fys, 2.5 Å

PDB Description: Crystal structure of Erk2 complex with KIM peptide derived from MKP3

PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d2fysa_:

Sequence, based on SEQRES records:

>d2fysa_ d.144.1.7 (A:) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
gpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtl
reikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyf
lyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyva
trwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsq
edlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqala
hpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgy

Sequence, based on observed residues (ATOM records):

>d2fysa_ d.144.1.7 (A:) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
gpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtl
reikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyf
lyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyva
trwyrapeimlnsgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqe
dlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalah
pyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgy

Timeline for d2fysa_:

• d2fysa_ first appeared in SCOP 1.73, called d2fysa1
  
• d2fysa_ appears in SCOPe 2.04
  
• d2fysa_ appears in SCOPe 2.06
  
• d2fysa_ appears in the current release, SCOPe 2.08