SCOP 1.73: Domain d2fypa1: 2fyp A:74-337

Lineage for d2fypa1 (2fyp A:74-337)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (4 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (1 protein)

6. Protein HSP90 [55876] (3 species)

7. Species Dog (Canis familiaris) [TaxId:9615] [103225] (20 PDB entries)

8. Domain d2fypa1: 2fyp A:74-337 [134387]
   automatically matched to d1u2oa_
   complexed with 1pe, pg4, rde; mutant

Details for d2fypa1

PDB Entry: 2fyp, 1.95 Å

PDB Description: grp94 in complex with the novel hsp90 inhibitor radester amine

PDB Compounds: (A:) Endoplasmin

SCOP Domain Sequences for d2fypa1:

Sequence, based on SEQRES records:

>d2fypa1 d.122.1.1 (A:74-337) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqstselig
qfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlke
easdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

Sequence, based on observed residues (ATOM records):

>d2fypa1 d.122.1.1 (A:74-337) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqstselig
qfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlke
easdyleldtiknlvkkysqfinfpiyvwssktktvwdwelmn

Timeline for d2fypa1:

• d2fypa1 is new in SCOP 1.73
  
• d2fypa1 appears in SCOP 1.75
  
• d2fypa1 appears in the current release, SCOPe 2.08, called d2fypa2