SCOPe 2.06: Domain d2fx8l2: 2fx8 L:108-213

Lineage for d2fx8l2 (2fx8 L:108-213)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d2fx8l2: 2fx8 L:108-213 [134289]
   Other proteins in same PDB: d2fx8h1, d2fx8h2, d2fx8i1, d2fx8i2, d2fx8j1, d2fx8j2, d2fx8k1, d2fx8k2, d2fx8l1, d2fx8m1, d2fx8n1, d2fx8o1
   automatically matched to d1rhha2

Details for d2fx8l2

PDB Entry: 2fx8, 2.2 Å

PDB Description: crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41

PDB Compounds: (L:) Fab 4E10

SCOPe Domain Sequences for d2fx8l2:

Sequence; same for both SEQRES and ATOM records:

>d2fx8l2 b.1.1.2 (L:108-213) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrge

Timeline for d2fx8l2:

• d2fx8l2 first appeared in SCOP 1.73
  
• d2fx8l2 appears in SCOPe 2.05
  
• d2fx8l2 appears in SCOPe 2.07
  
• d2fx8l2 appears in the current release, SCOPe 2.08