Lineage for d2fx8i2 (2fx8 I:114-227)

  1. Root: SCOPe 2.01
  2. 929298Class b: All beta proteins [48724] (174 folds)
  3. 929299Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 929300Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 931881Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)
  6. 933318Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)
  7. 933326Species Human (Homo sapiens) [TaxId:9606] [88575] (172 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 933397Domain d2fx8i2: 2fx8 I:114-227 [134283]
    Other proteins in same PDB: d2fx8h1, d2fx8i1, d2fx8j1, d2fx8k1, d2fx8l1, d2fx8l2, d2fx8m1, d2fx8m2, d2fx8n1, d2fx8n2, d2fx8o1, d2fx8o2
    automatically matched to d1ngzb2

Details for d2fx8i2

PDB Entry: 2fx8 (more details), 2.2 Å

PDB Description: crystal structure of hiv-1 neutralizing human fab 4e10 in complex with an aib-induced peptide encompassing the 4e10 epitope on gp41
PDB Compounds: (I:) Fab 4E10

SCOPe Domain Sequences for d2fx8i2:

Sequence; same for both SEQRES and ATOM records: (download)

>d2fx8i2 b.1.1.2 (I:114-227) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2fx8i2:

Click to download the PDB-style file with coordinates for d2fx8i2.
(The format of our PDB-style files is described here.)

Timeline for d2fx8i2: