SCOPe 2.06: Domain d2fvka2: 2fvk A:57-440

Lineage for d2fvka2 (2fvk A:57-440)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.9: Metallo-dependent hydrolases [51556] (19 families)
   the beta-sheet barrel is similarly distorted and capped by a C-terminal helix
   has transition metal ions bound inside the barrel

5. Family c.1.9.6: Hydantoinase (dihydropyrimidinase), catalytic domain [75073] (5 proteins)
   automatically mapped to Pfam PF13147

6. Protein Dihydropyrimidine amidohydrolase Pyd2 [141805] (2 species)

7. Species Yeast (Saccharomyces kluyveri) [TaxId:4934] [141806] (3 PDB entries)
   Uniprot Q9P903 57-440

8. Domain d2fvka2: 2fvk A:57-440 [134205]
   Other proteins in same PDB: d2fvka1, d2fvkb1, d2fvkc1, d2fvkd1
   automated match to d2ftya2
   complexed with duc, zn

Details for d2fvka2

PDB Entry: 2fvk, 2.4 Å

PDB Description: Crystal structure of dihydropyrimidinase from Saccharomyces kluyveri in complex with the substrate dihydrouracil

PDB Compounds: (A:) dihydropyrimidinase

SCOPe Domain Sequences for d2fvka2:

Sequence, based on SEQRES records:

>d2fvka2 c.1.9.6 (A:57-440) Dihydropyrimidine amidohydrolase Pyd2 {Yeast (Saccharomyces kluyveri) [TaxId: 4934]}
ggidahvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkl
dvdeyseqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglq
isdydimsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegea
tnraitlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchhh
gevesygvgidlssisespftnpddrfigskyicsppirpegtqksiwkgmnngtftivg
sdhcsynyyektstaskhrafdpennkngefryipnglpgvctrmpllydygylrgnlts
mmklveiqctnpakvygmypqkgs

Sequence, based on observed residues (ATOM records):

>d2fvka2 c.1.9.6 (A:57-440) Dihydropyrimidine amidohydrolase Pyd2 {Yeast (Saccharomyces kluyveri) [TaxId: 4934]}
ggidahvhvdeplkllgdvvdtmehatrsavaggtttvvafstqdvskkgpsalaesvkl
dvdeyseqtlycdyglhlilfqiekpsvearelldvqlqaayndygvssvkmfmtypglq
isdydimsamyatrkngfttmlhaengdmvkwmiealeeqgltdayyhgvsrpsivegea
tnraitlattmdtpilfvhvsspqaaevikqaqtkglkvyaetcpqyallsdaitrchgv
gidlssisespftnpddrfigskyicsppirpegtqksiwkgmnngtftivgsdhcsyny
yektstaskhrafdpennkngefryipnglpgvctrmpllydygylrgnltsmmklveiq
ctnpakvygmypqkgs

Timeline for d2fvka2:

• d2fvka2 first appeared in SCOP 1.73
  
• d2fvka2 appears in SCOPe 2.05
  
• d2fvka2 appears in SCOPe 2.07
  
• d2fvka2 appears in the current release, SCOPe 2.08