SCOPe 2.05: Domain d2ftda_: 2ftd A:

Lineage for d2ftda_ (2ftd A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 proteins)

6. Protein (Pro)cathepsin K [54028] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [54029] (45 PDB entries)
   Uniprot P43235 116-329 ! Uniprot P43235 115-329

8. Domain d2ftda_: 2ftd A: [134058]
   automated match to d2r6na1
   complexed with ili

Details for d2ftda_

PDB Entry: 2ftd, 2.55 Å

PDB Description: Crystal structure of Cathepsin K complexed with 7-Methyl-Substituted Azepan-3-one compound

PDB Compounds: (A:) cathepsin k

SCOPe Domain Sequences for d2ftda_:

Sequence; same for both SEQRES and ATOM records:

>d2ftda_ d.3.1.1 (A:) (Pro)cathepsin K {Human (Homo sapiens) [TaxId: 9606]}
apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsen
dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
knswgenwgnkgyilmarnknnacgianlasfpkm

Timeline for d2ftda_:

• d2ftda_ first appeared in SCOP 1.73, called d2ftda1
  
• d2ftda_ appears in SCOPe 2.04
  
• d2ftda_ appears in SCOPe 2.06
  
• d2ftda_ appears in the current release, SCOPe 2.08