SCOPe 2.08: Domain d2frha2: 2frh A:102-224

Lineage for d2frha2 (2frh A:102-224)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (14 superfamilies)
   core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

4. Superfamily a.4.5: 'Winged helix' DNA-binding domain [46785] (86 families)
   contains a small beta-sheet (wing)

5. Family a.4.5.28: MarR-like transcriptional regulators [63379] (20 proteins)
   The N- and C-terminal helical extensions to the common fold form the dimer interface

6. Protein Pleiotropic regulator of virulence genes, SarA [48292] (1 species)
   closely related to SarR but adopts a different fold; possible experimental artifact?

7. Species Staphylococcus aureus [TaxId:1280] [48293] (3 PDB entries)

8. Domain d2frha2: 2frh A:102-224 [133988]
   Other proteins in same PDB: d2frha3, d2frhb3
   automated match to d1fzpb_
   complexed with ca

Details for d2frha2

PDB Entry: 2frh, 2.5 Å

PDB Description: Crystal Structure of Sara, A Transcription Regulator From Staphylococcus Aureus

PDB Compounds: (A:) Staphylococcal accessory regulator A

SCOPe Domain Sequences for d2frha2:

Sequence; same for both SEQRES and ATOM records:

>d2frha2 a.4.5.28 (A:102-224) Pleiotropic regulator of virulence genes, SarA {Staphylococcus aureus [TaxId: 1280]}
aitkindcfellsmvtyadklkslikkefsisfeefavltyisenkekeyylkdiinhln
ykqpqvvkavkilsqedyfdkkrnehdertvlilvnaqqrkkiesllsrvnkriteanne
iel

Timeline for d2frha2:

• d2frha2 first appeared in SCOP 1.73, called d2frha1
  
• d2frha2 appears in SCOPe 2.07