SCOPe 2.08: Domain d2frab_: 2fra B:

Lineage for d2frab_ (2fra B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 proteins)

6. Protein automated matches [190264] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187102] (9 PDB entries)

8. Domain d2frab_: 2fra B: [133979]
   automated match to d1ms6a_
   complexed with crv

Details for d2frab_

PDB Entry: 2fra, 1.9 Å

PDB Description: human cathepsin s with cra-27934, a nitrile inhibitor

PDB Compounds: (B:) cathepsin S

SCOPe Domain Sequences for d2frab_:

Sequence; same for both SEQRES and ATOM records:

>d2frab_ d.3.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ilpdsvdwrekgcvtevkyqgscgacwafsavgaleaqlklktgklvslsaqnlvdcste
kygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpyg
redvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkey
wlvknswghnfgeegyirmarnkgnhcgiasfpsypei

Timeline for d2frab_:

• d2frab_ first appeared in SCOP 1.73, called d2frab1
  
• d2frab_ appears in SCOPe 2.07