SCOPe 2.06: Domain d2fr0a2: 2fr0 A:1448-1656

Lineage for d2fr0a2 (2fr0 A:1448-1656)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Erythromycin synthase, eryAI, 1st ketoreductase module [141909] (1 species)
   tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site

7. Species Saccharopolyspora erythraea [TaxId:1836] [141910] (2 PDB entries)
   Uniprot Q5UNP6 1448-1656! Uniprot Q5UNP6 1657-1915

8. Domain d2fr0a2: 2fr0 A:1448-1656 [133960]
   complexed with ndp

Details for d2fr0a2

PDB Entry: 2fr0, 1.81 Å

PDB Description: The first ketoreductase of the erythromycin synthase (crystal form 1)

PDB Compounds: (A:) Erythromycin synthase, EryAI

SCOPe Domain Sequences for d2fr0a2:

Sequence; same for both SEQRES and ATOM records:

>d2fr0a2 c.2.1.2 (A:1448-1656) Erythromycin synthase, eryAI, 1st ketoreductase module {Saccharopolyspora erythraea [TaxId: 1836]}
devsalryriewrptgageparldgtwlvakyagtadetstaarealesagarvrelvvd
arcgrdelaerlrsvgevagvlsllavdeaepeeaplalasladtlslvqamvsaelgcp
lwtvtesavatgpfervrnaahgalwgvgrvialenpavwgglvdvpagsvaelarhlaa
vvsggagedqlalradgvygrrwvraaap

Timeline for d2fr0a2:

• d2fr0a2 first appeared in SCOP 1.73
  
• d2fr0a2 appears in SCOPe 2.05
  
• d2fr0a2 appears in SCOPe 2.07
  
• d2fr0a2 appears in the current release, SCOPe 2.08