SCOP 1.73: Domain d2fpva1: 2fpv A:33-396

Lineage for d2fpva1 (2fpv A:33-396)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (1 family)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (18 proteins)

6. Protein Dihydroorotate dehydrogenase [51397] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51400] (8 PDB entries)

8. Domain d2fpva1: 2fpv A:33-396 [133926]
   automatically matched to d1d3ga_
   complexed with act, fmn, ilc, oro, so4

Details for d2fpva1

PDB Entry: 2fpv, 1.8 Å

PDB Description: Dual binding mode of a novel series of DHODH inhibitors

PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOP Domain Sequences for d2fpva1:

Sequence; same for both SEQRES and ATOM records:

>d2fpva1 c.1.4.1 (A:33-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
gderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrr

Timeline for d2fpva1:

• d2fpva1 is new in SCOP 1.73
  
• d2fpva1 appears in SCOP 1.75
  
• d2fpva1 appears in the current release, SCOPe 2.08, called d2fpva_