Lineage for d2fpta1 (2fpt A:30-396)

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 681098Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 681629Superfamily c.1.4: FMN-linked oxidoreductases [51395] (1 family) (S)
  5. 681630Family c.1.4.1: FMN-linked oxidoreductases [51396] (18 proteins)
  6. 681670Protein Dihydroorotate dehydrogenase [51397] (7 species)
  7. 681676Species Human (Homo sapiens) [TaxId:9606] [51400] (8 PDB entries)
  8. 681684Domain d2fpta1: 2fpt A:30-396 [133923]
    automatically matched to d1d3ga_
    complexed with act, fmn, ilb, oro, so4

Details for d2fpta1

PDB Entry: 2fpt (more details), 2.4 Å

PDB Description: Dual Binding Mode of a Novel Series of DHODH inhibitors
PDB Compounds: (A:) Dihydroorotate dehydrogenase, mitochondrial

SCOP Domain Sequences for d2fpta1:

Sequence, based on SEQRES records: (download)

>d2fpta1 c.1.4.1 (A:30-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
igadhrr

Sequence, based on observed residues (ATOM records): (download)

>d2fpta1 c.1.4.1 (A:30-396) Dihydroorotate dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
matgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvv
kelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiig
vggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaiga
dhrr

SCOP Domain Coordinates for d2fpta1:

Click to download the PDB-style file with coordinates for d2fpta1.
(The format of our PDB-style files is described here.)

Timeline for d2fpta1: