SCOP 1.75: Domain d2flrh1: 2flr H:16-257

Lineage for d2flrh1 (2flr H:16-257)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (35 PDB entries)
   Uniprot P08709 213-466
   Uniprot P08709 213-446
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d2flrh1: 2flr H:16-257 [133747]
   Other proteins in same PDB: d2flrt1, d2flrt2
   automatically matched to d1cvwh_
   complexed with 7nh

Details for d2flrh1

PDB Entry: 2flr, 2.35 Å

PDB Description: novel 5-azaindole factor viia inhibitors

PDB Compounds: (H:) Coagulation factor VII

SCOP Domain Sequences for d2flrh1:

Sequence; same for both SEQRES and ATOM records:

>d2flrh1 b.47.1.2 (H:16-257) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Timeline for d2flrh1:

• d2flrh1 first appeared in SCOP 1.73
  
• d2flrh1 is called d2flrh_ in SCOPe 2.01
  
• d2flrh1 appears in the current release, SCOPe 2.08, called d2flrh_