SCOP 1.73: Domain d2flpa2: 2flp A:27-299

Lineage for d2flpa2 (2flp A:27-299)

1. Root: SCOP 1.73

2. Class e: Multi-domain proteins (alpha and beta) [56572] (53 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain [100888] (4 proteins)
   contains a distinct 'fingers' domain possibly related to the C-terminal subdomain of hypothetical protein Ta1206 (1qw2)

6. Protein DNA polymerase iota [111295] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [111296] (8 PDB entries)

8. Domain d2flpa2: 2flp A:27-299 [133746]
   Other proteins in same PDB: d2flpa1
   automatically matched to d1t3na2
   complexed with doc

Details for d2flpa2

PDB Entry: 2flp, 2.4 Å

PDB Description: Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G)

PDB Compounds: (A:) DNA polymerase iota

SCOP Domain Sequences for d2flpa2:

Sequence; same for both SEQRES and ATOM records:

>d2flpa2 e.8.1.7 (A:27-299) DNA polymerase iota {Human (Homo sapiens) [TaxId: 9606]}
srvivhvdldcfyaqvemisnpelkdkplgvqqkylvvtcnyearklgvkklmnvrdake
kcpqlvlvngedltryremsykvtelleefspvverlgfdenfvdltemvekrlqqlqsd
elsavtvsghvynnqsinlldvlhirllvgsqiaaemreamynqlgltgcagvasnklla
klvsgvfkpnqqtvllpescqhlihslnhikeipgigyktakclealginsvrdlqtfsp
kilekelgisvaqriqklsfgednspvilsgpp

Timeline for d2flpa2:

• d2flpa2 is new in SCOP 1.73
  
• d2flpa2 appears in SCOP 1.75
  
• d2flpa2 appears in the current release, SCOPe 2.08