SCOPe 2.03: Domain d2flbh_: 2flb H:

Lineage for d2flbh_ (2flb H:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (41 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d2flbh_: 2flb H: [133710]
   Other proteins in same PDB: d2flbl1, d2flbl2, d2flbt1, d2flbt2
   automated match to d1cvwh_
   complexed with 6nh

Details for d2flbh_

PDB Entry: 2flb, 1.95 Å

PDB Description: discovery of a novel hydroxy pyrazole based factor ixa inhibitor

PDB Compounds: (H:) Coagulation factor VII

SCOPe Domain Sequences for d2flbh_:

Sequence; same for both SEQRES and ATOM records:

>d2flbh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Timeline for d2flbh_:

• d2flbh_ first appeared in SCOP 1.73, called d2flbh1
  
• d2flbh_ appears in SCOPe 2.02
  
• d2flbh_ appears in SCOPe 2.04
  
• d2flbh_ appears in the current release, SCOPe 2.08