SCOPe 2.08: Domain d2fgba_: 2fgb A:

Lineage for d2fgba_ (2fgb A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Prostaglandin d2 11-ketoreductase (akr1c3) [102051] (1 species)
   Aldo-keto reductase family 1 member c3

7. Species Human (Homo sapiens) [TaxId:9606] [102052] (50 PDB entries)
   Uniprot P42330

8. Domain d2fgba_: 2fgb A: [133427]
   automated match to d1ry0a_
   complexed with act, nap, p6g

Details for d2fgba_

PDB Entry: 2fgb, 1.35 Å

PDB Description: Crystal structure of human 17bet a-hydroxysteroid dehydrogenase type 5 in complexes with PEG and NADP

PDB Compounds: (A:) Aldo-keto reductase family 1 member C3

SCOPe Domain Sequences for d2fgba_:

Sequence, based on SEQRES records:

>d2fgba_ c.1.7.1 (A:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
mdskqqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeq
vglairskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspm
slkpgeelsptdengkvifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkp
glkykpvcnqvechpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpv
lcalakkhkrtpalialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgld
rnlhyfnsdsfashpnypysdey

Sequence, based on observed residues (ATOM records):

>d2fgba_ c.1.7.1 (A:) Prostaglandin d2 11-ketoreductase (akr1c3) {Human (Homo sapiens) [TaxId: 9606]}
mdskqqcvklndghfmpvlgfgtyappevprskalevtklaieagfrhidsahlynneeq
vglairskiadgsvkredifytsklwstfhrpelvrpalenslkkaqldyvdlylihspm
slkpgeifdivdlcttweamekckdaglaksigvsnfnrrqlemilnkpglkykpvcnqv
echpyfnrsklldfckskdivlvaysalgsqrdkrwvdpnspvlledpvlcalakkhkrt
palialryqlqrgvvvlaksyneqrirqnvqvfefqltaedmkaidgldrnlhyfnsdsf
ashpnypysdey

Timeline for d2fgba_:

• d2fgba_ first appeared in SCOP 1.73, called d2fgba1
  
• d2fgba_ appears in SCOPe 2.07