Class b: All beta proteins [48724] (180 folds) |
Fold b.50: Acid proteases [50629] (1 superfamily) barrel, closed; n=6, S=10, complex topology |
Superfamily b.50.1: Acid proteases [50630] (4 families) |
Family b.50.1.2: Pepsin-like [50646] (11 proteins) duplication: consists of two similar barrel domains N-terminal: barrel, partly opened; n*=6, S*=10 |
Protein beta-secretase (memapsin) [50671] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries) Uniprot P56817 58-446 ! Uniprot P56817 60-447 |
Domain d2fdpa_: 2fdp A: [133316] automated match to d1fkna_ complexed with frp |
PDB Entry: 2fdp (more details), 2.5 Å
SCOPe Domain Sequences for d2fdpa_:
Sequence, based on SEQRES records: (download)
>d2fdpa_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]} sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls styrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnweg ilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiig gidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlp kkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfr itilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavs achvhdefrtaavegpfvtldmedcgyn
>d2fdpa_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]} sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls styrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnweg ilglayaeiarpddslepffdslvkqthvpnlfslqlcgasvggsmiiggidhslytgsl wytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksi kaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrp vesqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaaveg pfvtldmedcgyn
Timeline for d2fdpa_: