SCOPe 2.08: Domain d2f2ka_: 2f2k A:

Lineage for d2f2ka_ (2f2k A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (156 PDB entries)
   Uniprot P15121

8. Domain d2f2ka_: 2f2k A: [132842]
   automated match to d1el3a_
   complexed with ndp, tgg

Details for d2f2ka_

PDB Entry: 2f2k, 1.94 Å

PDB Description: Aldose reductase tertiary complex with NADPH and DEG

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d2f2ka_:

Sequence; same for both SEQRES and ATOM records:

>d2f2ka_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
asrlllnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfheef

Timeline for d2f2ka_:

• d2f2ka_ first appeared in SCOP 1.73, called d2f2ka1
  
• d2f2ka_ appears in SCOPe 2.07