SCOP 1.75: Domain d2f13a1: 2f13 A:3-376

Lineage for d2f13a1 (2f13 A:3-376)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
   consists of six 4-stranded beta-sheet motifs; meander

4. Superfamily b.68.1: Sialidases [50939] (2 families)

5. Family b.68.1.1: Sialidases (neuraminidases) [50940] (9 proteins)

6. Protein Sialidase 2 (Neu2) [117274] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117275] (8 PDB entries)
   Uniprot Q9Y3R4

8. Domain d2f13a1: 2f13 A:3-376 [132687]
   automatically matched to d1vcua_
   complexed with dym, po4

Details for d2f13a1

PDB Entry: 2f13, 2.26 Å

PDB Description: crystal structure of the human sialidase neu2 in complex with 2',3'- dihydroxypropyl ether mimetic inhibitor

PDB Compounds: (A:) Sialidase 2

SCOP Domain Sequences for d2f13a1:

Sequence, based on SEQRES records:

>d2f13a1 b.68.1.1 (A:3-376) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
slpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdydap
thqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtranvt
rlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpayayr
klhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshlra
rvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythpthsw
qradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeei
vflmftlkqafpae

Sequence, based on observed residues (ATOM records):

>d2f13a1 b.68.1.1 (A:3-376) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
slpvlqkesvfqsgahayripallylpgqqsllafaeqraaelivlrrgdydapthqvqw
qaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqranvtrlcqvtstdhgrtws
sprdltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhpiqrpipsafcf
lshdhgrtwarghfvaqdtlecqvaeveeqrvvtlnarshlrarvqaqstndgldfqesq
lvkklvepppqgcqgsvisfpspraqwllythpthswqradlgaylnprppapeawsepv
llakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpae

Timeline for d2f13a1:

• d2f13a1 first appeared in SCOP 1.73
  
• d2f13a1 is called d2f13a_ in SCOPe 2.01
  
• d2f13a1 appears in the current release, SCOPe 2.08, called d2f13a_