SCOPe 2.08: Domain d2f12a_: 2f12 A:

Lineage for d2f12a_ (2f12 A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
   consists of six 4-stranded beta-sheet motifs; meander

4. Superfamily b.68.1: Sialidases [50939] (3 families)

5. Family b.68.1.1: Sialidases (neuraminidases) [50940] (10 proteins)

6. Protein Sialidase 2 (Neu2) [117274] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117275] (14 PDB entries)
   Uniprot Q9Y3R4

8. Domain d2f12a_: 2f12 A: [132686]
   automated match to d1vcua_
   complexed with htm, po4

Details for d2f12a_

PDB Entry: 2f12, 2.27 Å

PDB Description: crystal structure of the human sialidase neu2 in complex with 3- hydroxypropyl ether mimetic inhibitor

PDB Compounds: (A:) Sialidase 2

SCOPe Domain Sequences for d2f12a_:

Sequence, based on SEQRES records:

>d2f12a_ b.68.1.1 (A:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
slpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdydap
thqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtranvt
rlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpayayr
klhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshlra
rvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythpthsw
qradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeei
vflmftlkqafpaey

Sequence, based on observed residues (ATOM records):

>d2f12a_ b.68.1.1 (A:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
slpvlqkesvfqsgahayripallylpgqqsllafaeqraaelivlrrgdydapthqvqw
qaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtranvtrlcqvt
stdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhiqr
pipsafcflshdhgrtwarghfvaqdtlecqvaeveqrvvtlnarshlrarvqaqstndg
ldfqesqlvkklvepppqgcqgsvisfpspraqwllythpthswqradlgaylnprppap
eawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpaey

Timeline for d2f12a_:

• d2f12a_ first appeared in SCOP 1.73, called d2f12a1
  
• d2f12a_ appears in SCOPe 2.07