SCOPe 2.02: Domain d2ez9a2: 2ez9 A:9-182

Lineage for d2ez9a2 (2ez9 A:9-182)

1. Root: SCOPe 2.02

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
   the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology

6. Protein Pyruvate oxidase [88729] (2 species)

7. Species Lactobacillus plantarum [TaxId:1590] [88730] (7 PDB entries)

8. Domain d2ez9a2: 2ez9 A:9-182 [132628]
   Other proteins in same PDB: d2ez9a1, d2ez9a3, d2ez9b1, d2ez9b3
   automatically matched to d1powa2
   complexed with fad, mg, na, tdk

Details for d2ez9a2

PDB Entry: 2ez9, 1.6 Å

PDB Description: pyruvate oxidase variant f479w in complex with reaction intermediate analogue 2-phosphonolactyl-thiamin diphosphate

PDB Compounds: (A:) Pyruvate oxidase

SCOPe Domain Sequences for d2ez9a2:

Sequence; same for both SEQRES and ATOM records:

>d2ez9a2 c.36.1.5 (A:9-182) Pyruvate oxidase {Lactobacillus plantarum [TaxId: 1590]}
tnilagaavikvleawgvdhlygipggsinsimdalsaerdrihyiqvrheevgamaaaa
dakltgkigvcfgsagpggthlmnglydaredhvpvlaligqfgttgmnmdtfqemnenp
iyadvadynvtavnaatlphvideairrayahqgvavvqipvdlpwqqipaedw

Timeline for d2ez9a2:

• d2ez9a2 first appeared in SCOP 1.73
  
• d2ez9a2 appears in SCOPe 2.01
  
• d2ez9a2 appears in SCOPe 2.03
  
• d2ez9a2 appears in the current release, SCOPe 2.08