SCOP 1.75: Domain d2exba1: 2exb A:24-477

Lineage for d2exba1 (2exb A:24-477)

1. Root: SCOP 1.75

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
   contains a cluster of helices and an alpha+beta sandwich

4. Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (3 families)

5. Family e.3.1.3: Dac-like [144040] (3 proteins)
   Pfam PF02113; D-Ala-D-Ala carboxypeptidase 3 (S13) family; contains a large insertion comprising two subdomains: (d1) aplha+beta with topological similarity to one subunit of the DTD-like family ((69501)) and (d2) six-stranded beta-sandwich with a crossed-loop topology

6. Protein DD-carboxypeptidase DacB [144045] (1 species)
   Penicillin-binding protein 4

7. Species Escherichia coli [TaxId:562] [144046] (6 PDB entries)
   Uniprot P24228 22-477

8. Domain d2exba1: 2exb A:24-477 [132522]
   automatically matched to 2EX2 A:22-477
   complexed with fxm, gol

Details for d2exba1

PDB Entry: 2exb, 1.75 Å

PDB Description: crystal structure of penicillin binding protein 4 (dacb) from escherichia coli, complexed with flomox

PDB Compounds: (A:) Penicillin-binding protein 4

SCOP Domain Sequences for d2exba1:

Sequence, based on SEQRES records:

>d2exba1 e.3.1.3 (A:24-477) DD-carboxypeptidase DacB {Escherichia coli [TaxId: 562]}
deyitqlpaganlalmvqkvgasapaidyhsqqmalpastqkvitalaaliqlgpdfrft
ttletkgnvengvlkgdlvarfgadptlkrqdirnmvatlkksgvnqidgnvlidtsifa
shdkapgwpwndmtqcfsappaaaivdrncfsvslysapkpgdmafirvasyypvtmfsq
vrtlprgsaeaqyceldvvpgdlnrftltgclpqrseplplafavqdgasyagailkyel
kqagitwsgtllrqtqvnepgtvvaskqsaplhdllkimlkksdnmiadtvfrmigharf
nvpgtwragsdavrqilrqqagvdigntiiadgsglsrhnliapatmmqvlqyiaqhdne
lnfismlplagydgslqyraglhqagvdgkvsaktgslqgvynlagfittasgqrmafvq
ylsgyavepadqrnrriplvrfesrlykdiyqnn

Sequence, based on observed residues (ATOM records):

>d2exba1 e.3.1.3 (A:24-477) DD-carboxypeptidase DacB {Escherichia coli [TaxId: 562]}
deyitqlpaganlalmvqkvgasapaidyhsqqmalpastqkvitalaaliqlgpdfrft
ttletkgnvengvlkgdlvarfgadptlkrqdirnmvatlkksgvnqidgnvlidtsifa
shdkapgwpwndmtqcfsappaaaivdrncfsvslysapkpgdmafirvasyypvtmfsq
vrtlprgsaeaqyceldvvpgdlnrftltgclpqrseplplafavqdgasyagailkyel
kqagitwsgtllrqtqvnepgtvvaskqsaplhdllkimlkksdnmiadtvfrmigharf
nvpgtwragsdavrqilrqqagvdigntiiadgsglsrhnliapatmmqvlqyiaqhdne
lnfismlplagydgslqyraglhqagvdgkvsaktgslqgvynlagfittasgqrmafvq
ylsgyavriplvrfesrlykdiyqnn

Timeline for d2exba1:

• d2exba1 first appeared in SCOP 1.73
  
• d2exba1 is called d2exba_ in SCOPe 2.01
  
• d2exba1 appears in the current release, SCOPe 2.08, called d2exba_