SCOPe 2.07: Domain d2ex4b2: 2ex4 B:2-224

Lineage for d2ex4b2 (2ex4 B:2-224)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families)

5. Family c.66.1.42: AD-003 protein-like [117685] (3 proteins)
   Pfam PF05891; DUF858

6. Protein automated matches [190630] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187677] (2 PDB entries)

8. Domain d2ex4b2: 2ex4 B:2-224 [132517]
   Other proteins in same PDB: d2ex4a1, d2ex4a2, d2ex4b3
   automated match to d2ex4a1
   complexed with sah

Details for d2ex4b2

PDB Entry: 2ex4, 1.75 Å

PDB Description: Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine

PDB Compounds: (B:) adrenal gland protein AD-003

SCOPe Domain Sequences for d2ex4b2:

Sequence, based on SEQRES records:

>d2ex4b2 c.66.1.42 (B:2-224) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tseviedekqfyskaktywkqipptvdgmlggyghissidinssrkflqrflregpnktg
tscaldcgagigritkrlllplfrevdmvditedflvqaktylgeegkrvrnyfccglqd
ftpepdsydviwiqwvighltdqhlaeflrrckgslrpngiivikdnmaqegvilddvds
svcrdldvvrriicsaglsllaeerqenlpdeiyhvysfalr

Sequence, based on observed residues (ATOM records):

>d2ex4b2 c.66.1.42 (B:2-224) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tseviedekqfyskaktywkqipptvdgmlggyghissidinssrkflqrflrktgtsca
ldcgagigritkrlllplfrevdmvditedflvqaktylgeegkrvrnyfccglqdftpe
pdsydviwiqwvighltdqhlaeflrrckgslrpngiivikdnmaqegvilddvdssvcr
dldvvrriicsaglsllaeerqenlpdeiyhvysfalr

Timeline for d2ex4b2:

• d2ex4b2 first appeared in SCOP 1.73, called d2ex4b1
  
• d2ex4b2 appears in SCOPe 2.06
  
• d2ex4b2 appears in the current release, SCOPe 2.08