SCOPe 2.06: Domain d2ewpe_: 2ewp E:

Lineage for d2ewpe_ (2ewp E:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Orphan nuclear receptor ERR3 [81916] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [81917] (14 PDB entries)
   Uniprot O75454 233-458

8. Domain d2ewpe_: 2ewp E: [132492]
   automated match to d1tfca_
   complexed with txf

Details for d2ewpe_

PDB Entry: 2ewp, 2.3 Å

PDB Description: crystal structure of estrogen related receptor-3 (err-gamma) ligand binding domaind with tamoxifen analog gsk5182

PDB Compounds: (E:) Estrogen-related receptor gamma

SCOPe Domain Sequences for d2ewpe_:

Sequence, based on SEQRES records:

>d2ewpe_ a.123.1.1 (E:) Orphan nuclear receptor ERR3 {Human (Homo sapiens) [TaxId: 9606]}
ivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstlslad
qmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailqlvkky
ksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedprragk
mlmtlpllrqtstkavqhfyniklegkvpmhklflemle

Sequence, based on observed residues (ATOM records):

>d2ewpe_ a.123.1.1 (E:) Orphan nuclear receptor ERR3 {Human (Homo sapiens) [TaxId: 9606]}
ivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstlslad
qmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailqlvkky
ksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeedprragkmlmtl
pllrqtstkavqhfyniklegkvpmhklflemle

Timeline for d2ewpe_:

• d2ewpe_ first appeared in SCOP 1.73, called d2ewpe1
  
• d2ewpe_ appears in SCOPe 2.05
  
• d2ewpe_ appears in SCOPe 2.07
  
• d2ewpe_ appears in the current release, SCOPe 2.08