SCOPe 2.06: Domain d2ewpa_: 2ewp A:

Lineage for d2ewpa_ (2ewp A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Orphan nuclear receptor ERR3 [81916] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [81917] (14 PDB entries)
   Uniprot O75454 233-458

8. Domain d2ewpa_: 2ewp A: [132488]
   automated match to d1tfca_
   complexed with txf

Details for d2ewpa_

PDB Entry: 2ewp, 2.3 Å

PDB Description: crystal structure of estrogen related receptor-3 (err-gamma) ligand binding domaind with tamoxifen analog gsk5182

PDB Compounds: (A:) Estrogen-related receptor gamma

SCOPe Domain Sequences for d2ewpa_:

Sequence; same for both SEQRES and ATOM records:

>d2ewpa_ a.123.1.1 (A:) Orphan nuclear receptor ERR3 {Human (Homo sapiens) [TaxId: 9606]}
pynkivshllvaepekiyampdptvpdsdikalttlcdladrelvviigwakhipgfstl
sladqmsllqsawmeililgvvyrslsfedelvyaddyimdedqsklaglldlnnailql
vkkyksmklekeefvtlkaialansdsmhiedveavqklqdvlhealqdyeagqhmedpr
ragkmlmtlpllrqtstkavqhfyniklegkvpmhklflemlea

Timeline for d2ewpa_:

• d2ewpa_ first appeared in SCOP 1.73, called d2ewpa1
  
• d2ewpa_ appears in SCOPe 2.05
  
• d2ewpa_ appears in SCOPe 2.07
  
• d2ewpa_ appears in the current release, SCOPe 2.08