SCOPe 2.01: Domain d2etma_: 2etm A:

Lineage for d2etma_ (2etm A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Focal adhesion kinase 1 (fak) [103292] (2 species)
   PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103293] (4 PDB entries)

8. Domain d2etma_: 2etm A: [132363]
   automated match to d1mp8a_
   complexed with 7py

Details for d2etma_

PDB Entry: 2etm, 2.3 Å

PDB Description: Crystal Structure of Focal Adhesion Kinase Domain Complexed with 7H-Pyrrolo [2,3-d] pyrimidine Derivative

PDB Compounds: (A:) Focal adhesion kinase 1

SCOPe Domain Sequences for d2etma_:

Sequence, based on SEQRES records:

>d2etma_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwmapesi
nfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlysl
mtkcwaydpsrrprftelkaqlstileeekaq

Sequence, based on observed residues (ATOM records):

>d2etma_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
yeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqealt
mrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstal
ayleskrfvhrdiaarnvlvssndcvklgdfglsrymeklpikwmapesinfrrftsasd
vwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydps
rrprftelkaqlstileeekaq

Timeline for d2etma_:

• d2etma_ first appeared in SCOP 1.73, called d2etma1
  
• d2etma_ was called d2etma1 in SCOP 1.75
  
• d2etma_ appears in SCOPe 2.02
  
• d2etma_ appears in the current release, SCOPe 2.08