SCOP 1.73: Domain d2dm6b2: 2dm6 B:113-294

Lineage for d2dm6b2 (2dm6 B:113-294)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (16 proteins)
   N-terminal all-beta domain defines family

6. Protein Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase [110405] (1 species)

7. Species Guinea pig (Cavia porcellus) [TaxId:10141] [110406] (4 PDB entries)

8. Domain d2dm6b2: 2dm6 B:113-294 [131570]
   Other proteins in same PDB: d2dm6a1, d2dm6b1
   automatically matched to d1v3ta2
   complexed with imn, nap, tam

Details for d2dm6b2

PDB Entry: 2dm6, 2 Å

PDB Description: crystal structure of anti-configuration of indomethacin and leukotriene b4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13- reductase complex

PDB Compounds: (B:) NADP-dependent leukotriene B4 12-hydroxydehydrogenase

SCOP Domain Sequences for d2dm6b2:

Sequence; same for both SEQRES and ATOM records:

>d2dm6b2 c.2.1.1 (B:113-294) Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase {Guinea pig (Cavia porcellus) [TaxId: 10141]}
lplslalgtigmpgltayfgllevcgvkggetvlvsaaagavgsvvgqiaklkgckvvga
agsdekiaylkqigfdaafnyktvnsleealkkaspdgydcyfdnvggeflntvlsqmkd
fgkiaicgaisvynrmdqlppgpspesiiykqlriegfivyrwqgdvrekalrdlmkwvl
eg

Timeline for d2dm6b2:

• d2dm6b2 is new in SCOP 1.73
  
• d2dm6b2 appears in SCOP 1.75
  
• d2dm6b2 appears in the current release, SCOPe 2.08