SCOPe 2.05: Domain d2d0ta1: 2d0t A:12-403

Lineage for d2d0ta1 (2d0t A:12-403)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.266: Indolic compounds 2,3-dioxygenase-like [140958] (1 superfamily)
   multihelical; bundle, contains interrupted helices

4. Superfamily a.266.1: Indolic compounds 2,3-dioxygenase-like [140959] (3 families)
   contains heme-dependent enzymes

5. Family a.266.1.2: Indoleamine 2,3-dioxygenase-like [140963] (3 proteins)
   Pfam PF01231; contains extra N-terminal all-alpha subdomain of similar fold to the GST C-terminal domain (47615)

6. Protein Indoleamine 2,3-dioxygenase [140966] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [140967] (2 PDB entries)
   Uniprot P14902 12-403

8. Domain d2d0ta1: 2d0t A:12-403 [131093]
   Other proteins in same PDB: d2d0tb_
   complexed with hem, nhe, pim

Details for d2d0ta1

PDB Entry: 2d0t, 2.3 Å

PDB Description: Crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase

PDB Compounds: (A:) Indoleamine 2,3-dioxygenase

SCOPe Domain Sequences for d2d0ta1:

Sequence, based on SEQRES records:

>d2d0ta1 a.266.1.2 (A:12-403) Indoleamine 2,3-dioxygenase {Human (Homo sapiens) [TaxId: 9606]}
skeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhlt
dhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvl
anwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmq
erdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyeg
fwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsle
snpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqqpkenktsedp
skleakgtggtdlmnflktvrstteksllkeg

Sequence, based on observed residues (ATOM records):

>d2d0ta1 a.266.1.2 (A:12-403) Indoleamine 2,3-dioxygenase {Human (Homo sapiens) [TaxId: 9606]}
skeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhlt
dhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvl
anwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmq
erdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyeg
fwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsle
snpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqggtdlmnflkt
vrstteksllkeg

Timeline for d2d0ta1:

• d2d0ta1 first appeared in SCOP 1.73
  
• d2d0ta1 appears in SCOPe 2.04
  
• d2d0ta1 appears in SCOPe 2.06
  
• d2d0ta1 appears in the current release, SCOPe 2.08