SCOP 1.75: Domain d2cvzd2: 2cvz D:2-157

Lineage for d2cvzd2 (2cvz D:2-157)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (18 proteins)
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

6. Protein Hydroxyisobutyrate dehydrogenase [102171] (3 species)

7. Species Thermus thermophilus [TaxId:274] [102172] (2 PDB entries)
   structural genomics

8. Domain d2cvzd2: 2cvz D:2-157 [130897]
   Other proteins in same PDB: d2cvza1, d2cvzb1, d2cvzc1, d2cvzd1
   automatically matched to d1j3vc2
   complexed with ndp

Details for d2cvzd2

PDB Entry: 2cvz, 1.8 Å

PDB Description: Structure of hydroxyisobutyrate dehydrogenase from thermus thermophilus HB8

PDB Compounds: (D:) 3-hydroxyisobutyrate dehydrogenase

SCOP Domain Sequences for d2cvzd2:

Sequence; same for both SEQRES and ATOM records:

>d2cvzd2 c.2.1.6 (D:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}
ekvafiglgamgypmaghlarrfptlvwnrtfekalrhqeefgseavplervaearvift
clpttrevyevaealypylregtywvdatsgepeasrrlaerlrekgvtyldapvsggts
gaeagtltvmlggpeeavervrpflayakkvvhvgp

Timeline for d2cvzd2:

• d2cvzd2 first appeared in SCOP 1.73
  
• d2cvzd2 appears in SCOPe 2.01
  
• d2cvzd2 appears in the current release, SCOPe 2.08