SCOPe 2.08: Domain d2cr9a1: 2cr9 A:8-133

Lineage for d2cr9a1 (2cr9 A:8-133)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.297: WGR domain-like [142920] (1 superfamily)
   beta(4)-alpha-X-beta; 2 layers, a/b; antiparallel beta-sheet, order 51234; the beta-hairpin insetrion in strand 1 results in the formation of a beta-triangle structure

4. Superfamily d.297.1: WGR domain-like [142921] (1 family)

5. Family d.297.1.1: WGR domain [142922] (1 protein)
   Pfam PF05406; the conserved WGR motif maps to the C-end of strand 3, both large sidechains are exposed

6. Protein Poly [ADP-ribose] polymerase-1, PARP-1 [142923] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142924] (1 PDB entry)
   Uniprot P09874 517-642

8. Domain d2cr9a1: 2cr9 A:8-133 [130735]
   Other proteins in same PDB: d2cr9a2, d2cr9a3

Details for d2cr9a1

PDB Entry: 2cr9

PDB Description: solution structure of wgr domain of poly(adp-ribose) polymerase-1

PDB Compounds: (A:) Poly [ADP-ribose] polymerase-1

SCOPe Domain Sequences for d2cr9a1:

Sequence; same for both SEQRES and ATOM records:

>d2cr9a1 d.297.1.1 (A:8-133) Poly [ADP-ribose] polymerase-1, PARP-1 {Human (Homo sapiens) [TaxId: 9606]}
ksekrmkltlkggaavdpdsglehsahvlekggkvfsatlglvdivkgtnsyyklqlled
dkenrywifrswgrvgtvigsnkleqmpskedaiehfmklyeektgnawhsknftkypkk
fyplei

Timeline for d2cr9a1:

• d2cr9a1 first appeared in SCOP 1.73
  
• d2cr9a1 appears in SCOPe 2.07