SCOP 1.75: Domain d2cnbd1: 2cnb D:-1-381

Lineage for d2cnbd1 (2cnb D:-1-381)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)

7. Species Trypanosoma brucei [TaxId:5691] [89519] (2 PDB entries)

8. Domain d2cnbd1: 2cnb D:-1-381 [130639]
   automatically matched to d1gy8a_
   complexed with nad, ufg

Details for d2cnbd1

PDB Entry: 2cnb, 2.7 Å

PDB Description: trypanosoma brucei udp-galactose-4-epimerase in ternary complex with nad and the substrate analogue udp-4-deoxy-4-fluoro-alpha-d-galactose

PDB Compounds: (D:) udp-galactose-4-epimerase

SCOP Domain Sequences for d2cnbd1:

Sequence, based on SEQRES records:

>d2cnbd1 c.2.1.2 (D:-1-381) Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) {Trypanosoma brucei [TaxId: 5691]}
shmrvlvcggagyigshfvrallrdtnhsvvivdslvgthgksdhvetrenvarklqqsd
gpkppwadryaalevgdvrnedflngvftrhgpidavvhmcaflavgesvrdplkyydnn
vvgilrllqamllhkcdkiifsssaaifgnptmgsvstnaepidinakkspespygeskl
iaermirdcaeaygikgiclryfnacgahedgdigehyqgsthlipiilgrvmsdiapdq
rltihedastdkrmpifgtdyptpdgtcvrdyvhvcdlasahilaldyveklgpndksky
fsvfnlgtsrgysvrevievarkttghpipvrecgrregdpaylvaasdkarevlgwkpk
ydtleaimetswkfqrthpngya

Sequence, based on observed residues (ATOM records):

>d2cnbd1 c.2.1.2 (D:-1-381) Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) {Trypanosoma brucei [TaxId: 5691]}
shmrvlvcggagyigshfvrallrdtnhsvvivdslvgthgksdhvetrenvarklqqsd
gpkppwadryaalevgdvrnedflngvftrhgpidavvhmcaflavgesvrdplkyydnn
vvgilrllqamllhkcdkiifsssaaifgnptnaepidinakkspespygeskliaermi
rdcaeaygikgiclryfnacgahedgdigehyqgsthlipiilgrvmsdiadkrmpifgt
dyptpdgtcvrdyvhvcdlasahilaldyveklgpndkskyfsvfnlgtsrgysvrevie
varkttghpipvrecgrregdpaylvaasdkarevlgwkpkydtleaimetswkfqrthp
ngya

Timeline for d2cnbd1:

• d2cnbd1 first appeared in SCOP 1.73
  
• d2cnbd1 is called d2cnbd_ in SCOPe 2.01
  
• d2cnbd1 appears in the current release, SCOPe 2.08, called d2cnbd_