SCOPe 2.08: Domain d2cjmc_: 2cjm C:

Lineage for d2cjmc_ (2cjm C:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d2cjmc_: 2cjm C: [130544]
   Other proteins in same PDB: d2cjmb1, d2cjmb2, d2cjmd1, d2cjmd2
   automated match to d1aq1__
   complexed with atp, mg

Details for d2cjmc_

PDB Entry: 2cjm, 2.3 Å

PDB Description: Mechanism of CDK inhibition by active site phosphorylation: CDK2 Y15p T160p in complex with cyclin A structure

PDB Compounds: (C:) Cell division protein kinase 2

SCOPe Domain Sequences for d2cjmc_:

Sequence; same for both SEQRES and ATOM records:

>d2cjmc_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Timeline for d2cjmc_:

• d2cjmc_ first appeared in SCOP 1.73, called d2cjmc1
  
• d2cjmc_ appears in SCOPe 2.07