SCOP 1.73: Domain d2cgoa1: 2cgo A:13-349

Lineage for d2cgoa1 (2cgo A:13-349)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (12 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.6: Hypoxia-inducible factor HIF ihhibitor (FIH1) [82194] (1 protein)

6. Protein Hypoxia-inducible factor HIF ihhibitor (FIH1) [82195] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82196] (10 PDB entries)

8. Domain d2cgoa1: 2cgo A:13-349 [130427]
   automatically matched to d1mzea_
   complexed with fe, fmr, so4

Details for d2cgoa1

PDB Entry: 2cgo, 2.3 Å

PDB Description: factor inhibiting hif-1 alpha with fumarate

PDB Compounds: (A:) hypoxia-inducible factor 1 alpha inhibitor

SCOP Domain Sequences for d2cgoa1:

Sequence, based on SEQRES records:

>d2cgoa1 b.82.2.6 (A:13-349) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
sgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdtnlvyp
alkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnreemkfhefvekl
qdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnllligme
gnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnpdyerf
pnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkrieyplka
hqkvaimrniekmlgealgnpqevgpllntmikgryn

Sequence, based on observed residues (ATOM records):

>d2cgoa1 b.82.2.6 (A:13-349) Hypoxia-inducible factor HIF ihhibitor (FIH1) {Human (Homo sapiens) [TaxId: 9606]}
sgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelieneepvvltdtnlvyp
alkwdleylqenigngdfsvysasthkflyydekkmanfqnfknreemkfhefveklqdi
qqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwgqltsnllligmegnv
tpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqsqvdfdnpdyerfpnf
qnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykgaptpkrieyplkahqk
vaimrniekmlgealgnpqevgpllntmikgryn

Timeline for d2cgoa1:

• d2cgoa1 is new in SCOP 1.73
  
• d2cgoa1 appears in SCOP 1.75
  
• d2cgoa1 appears in the current release, SCOPe 2.08, called d2cgoa_