SCOP 1.73: Domain d2cemb1: 2cem B:101-199

Lineage for d2cemb1 (2cem B:101-199)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (2 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (8 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (1 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (230 PDB entries)

8. Domain d2cemb1: 2cem B:101-199 [130349]
   automatically matched to d1ajva_
   complexed with 2ah

Details for d2cemb1

PDB Entry: 2cem, 1.8 Å

PDB Description: p1' extended hiv-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold

PDB Compounds: (B:) pol protein

SCOP Domain Sequences for d2cemb1:

Sequence; same for both SEQRES and ATOM records:

>d2cemb1 b.50.1.1 (B:101-199) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d2cemb1:

• d2cemb1 is new in SCOP 1.73
  
• d2cemb1 appears in SCOP 1.75
  
• d2cemb1 appears in the current release, SCOPe 2.08, called d2cemb_