SCOPe 2.02: Domain d2ccia_: 2cci A:

Lineage for d2ccia_ (2cci A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (223 PDB entries)
   Uniprot P24941

8. Domain d2ccia_: 2cci A: [130242]
   Other proteins in same PDB: d2ccib1, d2ccib2, d2ccid1, d2ccid2
   automated match to d1aq1__
   protein/DNA complex; complexed with atp, mg

Details for d2ccia_

PDB Entry: 2cci, 2.7 Å

PDB Description: crystal structure of phospho-cdk2 cyclin a in complex with a peptide containing both the substrate and recruitment sites of cdc6

PDB Compounds: (A:) Cell division protein kinase 2

SCOPe Domain Sequences for d2ccia_:

Sequence; same for both SEQRES and ATOM records:

>d2ccia_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d2ccia_:

• d2ccia_ first appeared in SCOP 1.73, called d2ccia1
  
• d2ccia_ appears in SCOPe 2.01
  
• d2ccia_ appears in SCOPe 2.03
  
• d2ccia_ appears in the current release, SCOPe 2.08, called d2ccia2