SCOPe 2.06: Domain d2c60a1: 2c60 A:43-122

Lineage for d2c60a1 (2c60 A:43-122)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.2: CAD & PB1 domains [54277] (3 families)
   contain extra helix; similar heterodimerization modes; possibly related to the ubiquitin-like superfamily

5. Family d.15.2.2: PB1 domain [64225] (11 proteins)
   Pfam PF00564
   forms heterodimers, although not all PB1 domain pairs associate.

6. Protein Mitogen-activated protein kinase kinase kinase 3, MEKK 3 [142978] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142979] (3 PDB entries)
   Uniprot Q99759 42-123! Uniprot Q99759 43-122

8. Domain d2c60a1: 2c60 A:43-122 [129966]
   Other proteins in same PDB: d2c60a2
   complexed with ca, gol

Details for d2c60a1

PDB Entry: 2c60, 1.25 Å

PDB Description: crystal structure of human mitogen-activated protein kinase kinase kinase 3 isoform 2 phox domain at 1.25 a resolution

PDB Compounds: (A:) human mitogen-activated protein kinase kinase kinase 3 isoform 2

SCOPe Domain Sequences for d2c60a1:

Sequence; same for both SEQRES and ATOM records:

>d2c60a1 d.15.2.2 (A:43-122) Mitogen-activated protein kinase kinase kinase 3, MEKK 3 {Human (Homo sapiens) [TaxId: 9606]}
sdvrikfehngerriiafsrpvkyedvehkvttvfgqpldlhymnnelsillknqddldk
aidildrsssmkslrillls

Timeline for d2c60a1:

• d2c60a1 first appeared in SCOP 1.73
  
• d2c60a1 appears in SCOPe 2.05
  
• d2c60a1 appears in SCOPe 2.07
  
• d2c60a1 appears in the current release, SCOPe 2.08