SCOP 1.73: Domain d2c5na1: 2c5n A:1-296

Lineage for d2c5na1 (2c5n A:1-296)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (124 PDB entries)

8. Domain d2c5na1: 2c5n A:1-296 [129926]
   Other proteins in same PDB: d2c5nb1, d2c5nb2, d2c5nd1, d2c5nd2
   automatically matched to d1vywa_
   complexed with ck8

Details for d2c5na1

PDB Entry: 2c5n, 2.1 Å

PDB Description: differential binding of inhibitors to active and inactive cdk2 provides insights for drug design

PDB Compounds: (A:) Cell division protein kinase 2

SCOP Domain Sequences for d2c5na1:

Sequence; same for both SEQRES and ATOM records:

>d2c5na1 d.144.1.7 (A:1-296) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d2c5na1:

• d2c5na1 is new in SCOP 1.73
  
• d2c5na1 appears in SCOP 1.75
  
• d2c5na1 appears in the current release, SCOPe 2.08, called d2c5na_