SCOP 1.75: Domain d2c4gc1: 2c4g C:-1-298

Lineage for d2c4gc1 (2c4g C:-1-298)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (128 PDB entries)
   Uniprot P24941

8. Domain d2c4gc1: 2c4g C:-1-298 [129812]
   Other proteins in same PDB: d2c4gb1, d2c4gb2, d2c4gd1, d2c4gd2
   automatically matched to d1vywa_
   complexed with 514, so4

Details for d2c4gc1

PDB Entry: 2c4g, 2.7 Å

PDB Description: structure of cdk2-cyclin a with pha-533514

PDB Compounds: (C:) Cell division protein kinase 2

SCOP Domain Sequences for d2c4gc1:

Sequence; same for both SEQRES and ATOM records:

>d2c4gc1 d.144.1.7 (C:-1-298) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
vdmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d2c4gc1:

• d2c4gc1 first appeared in SCOP 1.73
  
• d2c4gc1 is called d2c4gc_ in SCOPe 2.01
  
• d2c4gc1 appears in the current release, SCOPe 2.08, called d2c4gc2