Lineage for d2c3ka1 (2c3k A:6-270)

  1. Root: SCOP 1.73
  2. 713694Class d: Alpha and beta proteins (a+b) [53931] (334 folds)
  3. 734668Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 734669Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 734710Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 734881Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  7. 734882Species Human (Homo sapiens) [TaxId:9606] [64405] (27 PDB entries)
  8. 734904Domain d2c3ka1: 2c3k A:6-270 [129738]
    automatically matched to d1ia8a_
    complexed with abo

Details for d2c3ka1

PDB Entry: 2c3k (more details), 2.6 Å

PDB Description: identification of a buried pocket for potent and selective inhibition of chk1: prediction and verification
PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOP Domain Sequences for d2c3ka1:

Sequence, based on SEQRES records: (download)

>d2c3ka1 d.144.1.7 (A:6-270) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhe
nvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgig
ithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefh
aepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhki
lvenpsaritipdikkdrwynkplk

Sequence, based on observed residues (ATOM records): (download)

>d2c3ka1 d.144.1.7 (A:6-270) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vedwdlvqtlgegaygevqlavnrvteeavavkivdmkrcpenikkeicinkmlnhenvv
kfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigith
rdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaep
vdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilve
npsaritipdikkdrwynkplk

SCOP Domain Coordinates for d2c3ka1:

Click to download the PDB-style file with coordinates for d2c3ka1.
(The format of our PDB-style files is described here.)

Timeline for d2c3ka1: