Lineage for d2c3ja1 (2c3j A:6-270)

  1. Root: SCOPe 2.03
  2. 1396887Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1433536Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1433537Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1433619Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1433985Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  7. 1433986Species Human (Homo sapiens) [TaxId:9606] [64405] (70 PDB entries)
  8. 1434029Domain d2c3ja1: 2c3j A:6-270 [129737]
    automatically matched to d1ia8a_
    complexed with dbq, so3

Details for d2c3ja1

PDB Entry: 2c3j (more details), 2.1 Å

PDB Description: identification of a buried pocket for potent and selective inhibition of chk1: prediction and verification
PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2c3ja1:

Sequence, based on SEQRES records: (download)

>d2c3ja1 d.144.1.7 (A:6-270) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhe
nvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgig
ithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefh
aepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhki
lvenpsaritipdikkdrwynkplk

Sequence, based on observed residues (ATOM records): (download)

>d2c3ja1 d.144.1.7 (A:6-270) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vedwdlvqtlgegevqlavnrvteeavavkivdmkrenikkeicinkmlnhenvvkfygh
rregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdikp
enlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvws
cgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsar
itipdikkdrwynkplk

SCOPe Domain Coordinates for d2c3ja1:

Click to download the PDB-style file with coordinates for d2c3ja1.
(The format of our PDB-style files is described here.)

Timeline for d2c3ja1: