SCOP 1.75: Domain d2c2tb1: 2c2t B:1-186

Lineage for d2c2tb1 (2c2t B:1-186)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (25 PDB entries)

8. Domain d2c2tb1: 2c2t B:1-186 [129685]
   automatically matched to d1drf__
   complexed with 39b, 39e, gol, ndp

Details for d2c2tb1

PDB Entry: 2c2t, 1.5 Å

PDB Description: human dihydrofolate reductase complexed with nadph and 2,4-diamino-5- ((7,8-dicarbaundecaboran-7-yl)methyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate

PDB Compounds: (B:) dihydrofolate reductase

SCOP Domain Sequences for d2c2tb1:

Sequence; same for both SEQRES and ATOM records:

>d2c2tb1 c.71.1.1 (B:1-186) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d2c2tb1:

• d2c2tb1 first appeared in SCOP 1.73
  
• d2c2tb1 is called d2c2tb_ in SCOPe 2.01
  
• d2c2tb1 appears in the current release, SCOPe 2.08, called d2c2tb_