Lineage for d2c2tb1 (2c2t B:1-186)

  1. Root: SCOP 1.73
  2. 681097Class c: Alpha and beta proteins (a/b) [51349] (141 folds)
  3. 707730Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 707731Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families) (S)
  5. 707732Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)
  6. 707842Protein Dihydrofolate reductases, eukaryotic type [53605] (4 species)
  7. 707867Species Human (Homo sapiens) [TaxId:9606] [53607] (25 PDB entries)
  8. 707873Domain d2c2tb1: 2c2t B:1-186 [129685]
    automatically matched to d1drf__
    complexed with 39b, 39e, gol, ndp

Details for d2c2tb1

PDB Entry: 2c2t (more details), 1.5 Å

PDB Description: human dihydrofolate reductase complexed with nadph and 2,4-diamino-5- ((7,8-dicarbaundecaboran-7-yl)methyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate
PDB Compounds: (B:) dihydrofolate reductase

SCOP Domain Sequences for d2c2tb1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2c2tb1 c.71.1.1 (B:1-186) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOP Domain Coordinates for d2c2tb1:

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Timeline for d2c2tb1: