Lineage for d2c2sa_ (2c2s A:)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2477518Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2477519Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2477520Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 2477723Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2477771Species Human (Homo sapiens) [TaxId:9606] [53607] (75 PDB entries)
  8. 2477780Domain d2c2sa_: 2c2s A: [129682]
    automated match to d1drf__
    complexed with 34b, gol, ndp

Details for d2c2sa_

PDB Entry: 2c2s (more details), 1.4 Å

PDB Description: human dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d2c2sa_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2c2sa_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2c2sa_:

Click to download the PDB-style file with coordinates for d2c2sa_.
(The format of our PDB-style files is described here.)

Timeline for d2c2sa_: