SCOPe 2.06: Domain d2bxva_: 2bxv A:

Lineage for d2bxva_ (2bxv A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)

5. Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)

6. Protein automated matches [190228] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187000] (8 PDB entries)

8. Domain d2bxva_: 2bxv A: [129445]
   automated match to d1d3ga_
   complexed with 3ft, act, fmn, oro, so4

Details for d2bxva_

PDB Entry: 2bxv, 2.15 Å

PDB Description: dual binding mode of a novel series of dhodh inhibitors

PDB Compounds: (A:) dihydroorotate dehydrogenase

SCOPe Domain Sequences for d2bxva_:

Sequence, based on SEQRES records:

>d2bxva_ c.1.4.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
igadhrr

Sequence, based on observed residues (ATOM records):

>d2bxva_ c.1.4.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
matgderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpv
giaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvn
vsspntaglgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkelg
idglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvggv
ssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhrr

Timeline for d2bxva_:

• d2bxva_ first appeared in SCOP 1.73, called d2bxva1
  
• d2bxva_ appears in SCOPe 2.05
  
• d2bxva_ appears in SCOPe 2.07
  
• d2bxva_ appears in the current release, SCOPe 2.08