SCOP 1.75: Domain d2brna1: 2brn A:6-276

Lineage for d2brna1 (2brn A:6-276)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
   CaMK group; CAMKL subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [64405] (35 PDB entries)

8. Domain d2brna1: 2brn A:6-276 [129003]
   automatically matched to d1ia8a_
   complexed with df1

Details for d2brna1

PDB Entry: 2brn, 2.8 Å

PDB Description: structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOP Domain Sequences for d2brna1:

Sequence, based on SEQRES records:

>d2brna1 d.144.1.7 (A:6-276) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhe
nvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgig
ithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefh
aepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhki
lvenpsaritipdikkdrwynkplkkgakrp

Sequence, based on observed residues (ATOM records):

>d2brna1 d.144.1.7 (A:6-276) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vedwdlvqtlgegaygevqlavnrvteeavavkivdmkrcpenikkeicinkmlnhenvv
kfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigith
rdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaep
vdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilve
npsaritipdikkdrwynkplkkgakrp

Timeline for d2brna1:

• d2brna1 first appeared in SCOP 1.73
  
• d2brna1 appears in SCOPe 2.01
  
• d2brna1 appears in the current release, SCOPe 2.08, called d2brna_