Lineage for d2brma_ (2brm A:)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2979545Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2979546Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2979693Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2983276Protein automated matches [190091] (20 species)
    not a true protein
  7. 2983389Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)
  8. 2983905Domain d2brma_: 2brm A: [129002]
    automated match to d3nlba_
    complexed with dfz

Details for d2brma_

PDB Entry: 2brm (more details), 2.2 Å

PDB Description: structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity
PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d2brma_:

Sequence, based on SEQRES records: (download)

>d2brma_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
edwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkmlnhen
vvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigi
thrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefha
epvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkil
venpsaritipdikkdrwynkplkkgak

Sequence, based on observed residues (ATOM records): (download)

>d2brma_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
edwdlvqtlgegaygevqlavnrvteeavavkivdmcpenikkeicinkmlnhenvvkfy
ghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdi
kpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdv
wscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenps
aritipdikkdrwynkplkkgak

SCOPe Domain Coordinates for d2brma_:

Click to download the PDB-style file with coordinates for d2brma_.
(The format of our PDB-style files is described here.)

Timeline for d2brma_: